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Review of the biotechnologies and tests used for precancerous cervical lesions diagnosis Ruxandra Viorica Stanculescu, Elvira Bratila, Vasilica Bausic, Teodora Camelia Vladescu, Florina Vasilescu, Alexandra Bausic, Costin Berceanu This paper draws on the author s extensive experience in the clinical research focused on the implementation of the new biotechnologies able to identify precancerous cervical lesions and is intended to be a systematic approach to new achievements.

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The goal of this review is to provide updated information concerning the significance of each biotechnology used in clinical medicine to screen women for cervical cancer or to allow a pertinent discrimination between spontaneous remission lesions and progressive lesions.

The data is arranged according to the most widely used biotechnologies and the worldwide recommendations of specialized guidelines.

Nicolae Iorga

Angiogenesis versus arteriogenesis Anna Rizzi, Vincenzo Benagiano, Domenico Ribatti In the vascular system, angiogenesis and arteriogenesis play a unique yet equally important role in both health and webber fat burner 66 volum. Angiogenesis, the formation of new blood vessels from a preexisting vascular bed, occurs naturally during wound healing, the female menstrual cycle and pregnancy.

It plays a critical role in tissue growth and repair, and is a highly controlled process that is dependent on an intricate balance of both pro-angiogenic to stimulate and anti-angiogenic to negatively regulate the phenomenon factors. Otherwise, the term arteriogenesis refers to anatomic transformation of preexisting arterioles with increasing lumen area and wall thickness, due to a thick muscular layer and purchasing of visco-elastic and vasomotor capacities.

Writer, Poet, Professor, Literary Critic, Politician Profession Historian, Philosopher Signature In parallel with his scientific contributions, Nicolae Iorga was a prominent right-of-centre activist, whose political theory bridged conservatismRomanian nationalismand agrarianism.

Arteriogenesis differs from angiogenesis in several aspects, the most important being the dependence of angiogenesis on hypoxia and the dependence of arteriogenesis on inflammation. The expression of growth factors and the cooperation of surrounding and infiltrating cells seem to be essential in orchestrating the complex processes during arteriogenesis. Triple positive breast cancer - a novel category?

Breast cancer has been divided in subtypes depending on the presence of hormone receptors HRs for estrogen and progesterone and human epidermal growth factor receptor 2 HER2 gene amplification. We aim to review current evidence on this subtype of BC, from the molecular mechanisms regulating its behavior to the current standard treatment outcome in order to establish whether it qualifies as a new distinct subtype of BC. Its biology is dominated by the crosstalks between HR pathway and HER2 pathway, which might be responsible for the development of rapid resistance to treatment, because of estrogen receptor up-regulation and alternate regulatory pathways activation when anti-HER2 agents are used.

However, most of the clinical evidence is provided by retrospective trials with multiple potential biases. Autophagy is present at a basal level in all mammals and is regulated by some conditions, such as oxidative stress, starvation or hypoxia.

In aged tissues, increased but also decreased expression of autophagy-specific proteins, Beclin 1, LC3, Atg5 and Atg7 has been reported. Likewise, it could be shown that the lifespan of yeast, nematodes and flies is prolonged by pharmacologically stimulated autophagy using exogenous administered spermidine.

Autophagy is potentially implicated in acute lung injury and sepsis, two main causes of morbidity and mortality worldwide.

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Finally, a quite recent study supports the hypothesis that autophagy might be useful in vascular disease prevention by stimulating cholesterol efflux, which leads to inhibition of necrotic core formation and lipid accumulation. However, cases of regression have been reported. Recent reviews cover only certain aspects of this disease; therefore, this paper s aim is to cover all the relevant aspects for medical practice, such as clinical, histological and therapeutic details.

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BD may affect all regions of the skin and mucosa, but in accordance with the region and etiologic factor, it may embrace different clinical forms, webber fat burner 66 volum of them very similar with other skin lesions. Dermoscopy may prove useful for establishing a clinical diagnosis. Several webber fat burner 66 volum have been encountered and may help distinguishing from other diseases. When in doubt, puncture biopsy or complete excision may be performed in order to obtain histological data that could define BD.

Different morphological aspects of the involved components are described in order to reduce the risk of misdiagnose. In order for the approach to be complete, relevant information about treatment has been presented, underlining the pros and cons of each available therapy.

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A systematic review of the possible carcinogenic role of the aristolochic acid Tivadar Bara Jr. AA is also shown to be involved in the genesis of the upper urinary tract urothelial carcinoma UTUC and some other cancers, but its tumorigenic role is far to be understood. We performed a systematic literature review regarding the involvement of AA in malignant processes and molecular pathways of carcinogenesis.

Twenty representative papers were selected webber fat burner 66 volum this review. These papers reveal that AA exposure increases the risk for UTUC, renal cell carcinoma, hepatocellular carcinoma, gastric and small intestine cancer.

  • Вот почему я как можно меньше говорил Элвину о его предшественниках: это вряд ли помогло бы ему в его теперешнем настроении.
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The role of AA in lymphomagenesis is also proposed. For further understanding of AA s role in tumorigenesis, the exploration of the AA s molecular signature is necessary. The ultraviolet influence upon soft eye tissues Sanda Jurja, Malina Coman, Mihaela-Cezarina Hincu The climate changes, which occurred during the last decades, put all living species in front of new challenges.

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Human biology is no exception to it, all tissues have to face new effects, with unpredictable consequences. Many cancers, mainly affecting the skin, but also many of the eye various structures diseases, have ultraviolet radiation as recognized causative agent. The aim of our work is to highlight the changes that can occur after exposure to ultraviolet radiations of soft tissues, including eye structures, by reviewing data from the scientific literature regarding the matter.

Responsible for severe diseases, including cancer, ultraviolet negative effects on various soft tissues can be limited by better comprehension.

Their knowledge can contribute to improving public health, by finding new preventive methods, which might represent the foundation of effective public health programs.

Role of genetic polymorphism in nutritional supplementation therapy in personalized medicine Nicolae Ovidiu Penes, Bernard Weber, Silviu Dumitru Paun Genetic-guided nutritional supplementation therapy in personalized medicine is the type of treatment that prevents and acts against errors during the copying process of a cell s deoxyribonucleic acid DNAmistakes that lead to diversification in the DNA sequence at certain locations, called single nucleotide polymorphisms SNPs.

Positive results are quickly achieved using one of the four types of therapy.

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These types are: personalized, when individual human genetic variations drive individual treatment, preventive, with a tailored healthcare strategy and therapeutic preventive drugs and vaccines, participatory, when empowered patients make informed choices and take responsibility of their own health and predictive, using a proactive approach to health and medicine.

Three-dimensional organ scanning reveals brain edema reduction in a rat model of stroke treated with an aquaporin 4 inhibitor Elena Silvia Popescu, Ionica Pirici, Raluca Niculina Ciurea, Tudor-Adrian Balseanu, Bogdan Catalin, Claudiu Margaritescu, Laurentiu Mogoanta, Sorin Hostiuc, Daniel Pirici Stroke is one of the most important cause of death and disability, especially when considering the increasing life expectancy worldwide, with ischemic stroke being much more common than hemorrhages.

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In the physiopathological chain of ischemic stroke, brain edema is one first element that if attended to might reduce tissue necrosis, penumbra, and increase functional recovery. Aquaporin 4 AQP4 has been found to be the most important water channel in the brain, and its inhibition before inducing focal ischemia in an animal model of webber fat burner 66 volum proved to alleviate the pathology and improve clinical recovery.

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In this study, we have treated a rat model of ischemic stroke with the AQP4 inhibitor TGN after inducing the lesion, and performed for the first time a direct histopathological evaluation of the brain and infarct s volume. Besides utilizing immunohistochemistry targeting the growth-associated protein GAP in order to delineate the infarct regions, we have used the Cavalieri s principle of tissue volume measurements starting form seriate sections, and for the first time in neuropathology, we have utilized a high-resolution object scanner to assess global brain volume changes.

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